MURINE LEUKEMIA VIRUS Meaning and
Definition
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Murine leukemia virus (MLV) is a type of retrovirus that commonly infects mice, belonging to the family Retroviridae and the genus Gammaretrovirus. It was first discovered in the 1950s as a causative agent of lymphoid tumors in laboratory mice. MLV has since served as an important model for studying viral oncogenesis and immunology.
MLV is an enveloped virus with a single-stranded RNA genome. It is capable of integrating its genetic material into the host cell's genome, allowing it to replicate and perpetuate through cell division. MLV primarily infects lymphocytes and bone marrow cells, leading to malignant transformation of these cells and the development of leukemia or lymphoma.
The transmission of MLV primarily occurs through horizontal routes, such as direct contact between infected and susceptible mice, but it can also be transmitted vertically from infected mothers to their offspring via the placenta or milk.
In the laboratory setting, MLV is commonly used as a tool for gene delivery and genetic engineering due to its ability to efficiently integrate foreign genes into the host cell genome. This has enabled various studies on the molecular mechanisms of cancer, immunotherapy, and gene therapy.
While MLV is relatively harmless to humans, caution should be exercised in laboratory settings to prevent accidental transmission and potential zoonotic infections.
Common Misspellings for MURINE LEUKEMIA VIRUS
- nurine leukemia virus
- kurine leukemia virus
- jurine leukemia virus
- myrine leukemia virus
- mhrine leukemia virus
- mjrine leukemia virus
- mirine leukemia virus
- m8rine leukemia virus
- m7rine leukemia virus
- mueine leukemia virus
- mudine leukemia virus
- mufine leukemia virus
- mutine leukemia virus
- mu5ine leukemia virus
- mu4ine leukemia virus
- murune leukemia virus
- murjne leukemia virus
- murkne leukemia virus
- murone leukemia virus
- mur9ne leukemia virus
