Murine Gastroenteritis Viruses (MGV) refer to a group of viruses that primarily infect rodents, particularly mice. These viruses are classified within the Caliciviridae family, which is a family of non-enveloped, single-stranded RNA viruses. MGVs are known to cause gastroenteritis, which is the inflammation of the stomach and intestines, in rodents.
The main genus of MGV is known as the Murine Norovirus (MNV), which has been extensively studied due to its similarities with human norovirus, a common cause of acute gastroenteritis in humans. MNV infection in mice results in symptoms such as diarrhea, weight loss, dehydration, and even death, especially in immunocompromised animals.
MGVs are highly contagious and primarily transmitted through the fecal-oral route. Infected mice shed the virus in their feces, which can contaminate the environment, food, and water sources, leading to subsequent infections among susceptible mice. These viruses can persist in the environment for an extended period, making them a significant concern in laboratory animal facilities and rodent colonies.
Research on MGVs has provided insights into the pathogenesis of noroviruses and has served as a useful mouse model for studying viral gastroenteritis. Additionally, their study has implications for understanding host immune responses, antiviral development, and vaccine design against human norovirus infections.
In conclusion, Murine Gastroenteritis Viruses are a group of viruses that primarily infect rodents, causing gastroenteritis similar to human norovirus. They are highly contagious, transmitted through the fecal-oral route, and have significant implications for both veterinary and human health.
