Murine Encephalomyelitis Virus (MEV) is a species of virus that belongs to the family Picornaviridae. It is a single-stranded RNA virus that specifically infects mice, leading to neurological disorders and inflammation in the brain and spinal cord, known as encephalomyelitis.
MEV is primarily transmitted through the respiratory route, meaning it can be spread through the inhalation of respiratory droplets or direct contact with contaminated surfaces. The virus enters the body through the nasal passages, where it replicates in the respiratory tract before disseminating to the central nervous system.
Infection with MEV can result in a range of clinical manifestations, including paralysis, ataxia, tremors, seizures, and death. The severity of the disease largely depends on the strain of the virus and the host's immune response. Some strains of MEV can cause acute encephalomyelitis, while others may lead to a chronic, persistent infection.
Research on MEV has been instrumental in understanding the pathogenesis of viral encephalomyelitis and has served as a model for studying similar diseases in humans. Additionally, MEV has provided valuable insights into the mechanisms of viral persistence and immune responses in the central nervous system.
Efforts to control MEV involve implementing strict biosecurity measures, such as quarantine, disinfection, and isolation of infected animals. Vaccines have also been developed to prevent or reduce the severity of MEV infections in mice.
