Murine AIDS, also known as mouse AIDS or MAIDS, is a term used to describe a viral disease that affects mice and other rodent species. It is caused by a specific type of retrovirus known as a murine leukemia virus (MLV) or murine immunodeficiency virus (MIDV).
Murine AIDS is similar in its pathogenesis and clinical manifestations to human AIDS (Acquired Immunodeficiency Syndrome). However, the retrovirus that causes murine AIDS is distinct from the human immunodeficiency virus (HIV) that leads to human AIDS. Therefore, murine AIDS is not transmissible to humans, and there is no direct correlation between the two diseases.
In infected mice, the retrovirus replicates and targets the immune system, eventually leading to the destruction of immune cells and a weakened immune response. This compromises the mouse's ability to fight off infections and increases susceptibility to other diseases. Common symptoms of murine AIDS include weight loss, lethargy, decreased activity, and increased susceptibility to opportunistic infections.
Murine AIDS has been extensively studied in laboratory mice, particularly when examining the function of the immune system and potential treatments for viral infections or immune-related diseases. It serves as an important animal model for understanding the progression and consequences of immunodeficiency diseases.
In summary, murine AIDS is a viral disease caused by specific retroviruses that affects mice and other rodent species. It shares some similarities with human AIDS but is not transmissible to humans.
