How Do You Spell GLUTATHIONE SYNTHETASE?

Pronunciation: [ɡlˌuːtɐθˈa͡ɪ͡əni sˈɪnθɪtˌe͡ɪs] (IPA)

The spelling of "Glutathione Synthetase" can be explained using the International Phonetic Alphabet (IPA). The word is pronounced as "ɡluːˈtæθiəʊn sɪnθəteɪz". The initial "G" is pronounced as a voiced velar stop, followed by "luː" which represents the "oo" sound as in "moon". "tæθiəʊn" represents the main sound in the word, which is a diphthong, with "θ" and "iː" pronounced together. The word ends with "sɪnθəteɪz", with the "s" pronounced as a voiceless alveolar fricative.

GLUTATHIONE SYNTHETASE Meaning and Definition

1. Glutathione synthetase is an enzyme responsible for the biosynthesis of glutathione, a major antioxidant molecule found in various organisms, including mammals. Glutathione plays a crucial role in protecting cells against oxidative stress, which is caused by reactive oxygen species (ROS) and free radicals.

   The process of glutathione biosynthesis starts with the condensation of glycine and cysteine in the presence of adenosine triphosphate (ATP) to produce gamma-glutamylcysteine. This reaction is catalyzed by the enzyme gamma-glutamylcysteine synthetase. Glutathione synthetase then facilitates the addition of a glycine molecule to the gamma-glutamylcysteine, resulting in the formation of glutathione.

   Glutathione is vital for maintaining the cellular redox balance, as it participates in various antioxidant defense mechanisms. It acts as a reducing agent, helping to neutralize ROS and free radicals, thereby preventing damage to cellular components such as DNA, proteins, and lipids. Additionally, glutathione is involved in the detoxification processes of xenobiotics and harmful compounds, making it crucial for liver function.

   Deficiencies in glutathione synthetase activity or genetic mutations affecting this enzyme can lead to various disorders, including hemolytic anemia, a condition characterized by the destruction of red blood cells. Studies have also suggested that alterations in glutathione synthesis and metabolism may contribute to the development of certain diseases, such as neurodegenerative disorders, cancer, and cardiovascular diseases.

   Overall, glutathione synthetase plays a fundamental role in the cellular antioxidant defense system, redox homeostasis, and detoxification processes, making it a crucial enzyme for

Common Misspellings for GLUTATHIONE SYNTHETASE

• flutathione synthetase
• vlutathione synthetase
• blutathione synthetase
• hlutathione synthetase
• ylutathione synthetase
• tlutathione synthetase
• gkutathione synthetase
• gputathione synthetase
• goutathione synthetase
• glytathione synthetase
• glhtathione synthetase
• gljtathione synthetase
• glitathione synthetase
• gl8tathione synthetase
• gl7tathione synthetase
• glurathione synthetase
• glufathione synthetase
• glugathione synthetase
• gluyathione synthetase
• glu6athione synthetase

Etymology of GLUTATHIONE SYNTHETASE

The word "glutathione" comes from the Greek roots "gluto" meaning "glue" and "thio" meaning "sulfur". Glutathione is a thiol compound involved in various cellular processes.

The word "synthetase" is derived from the Greek roots "syn" meaning "together" and "thetase" meaning "to place or set". In biochemistry, a synthetase is an enzyme responsible for creating or synthesizing a specific molecule or compound in the body.

Therefore, "glutathione synthetase" is an enzyme responsible for the synthesis of glutathione, the cellular "glue" containing sulfur atoms.