PDGFB stands for Platelet-Derived Growth Factor B, which is a protein involved in cell growth and division. It belongs to the family of platelet-derived growth factors and plays a crucial role in various cellular processes such as embryonic development, tissue repair, angiogenesis, and regulation of blood vessel formation.
PDGFB is produced by several cells, including platelets, macrophages, and smooth muscle cells. It acts through binding to its receptor, known as PDGFRβ (Platelet-Derived Growth Factor Receptor Beta), located on the surface of target cells. This binding activates signaling pathways involved in cell proliferation, migration, and differentiation.
The protein is composed of multiple domains, including a signal peptide that facilitates secretion and a C-terminal domain responsible for receptor binding. It is expressed in various tissues throughout the body, including the lungs, kidneys, heart, and brain.
Abnormal expression or dysregulation of PDGFB has been associated with several pathological conditions. Overexpression of PDGFB has been observed in various cancers, including gliomas and fibrosarcomas, indicating its involvement in tumor growth and angiogenesis. Conversely, mutations or dysfunctional signaling of PDGFB and its receptor have been linked to disorders such as renal and cardiovascular diseases.
Considering its significant role in diverse physiological and pathological processes, PDGFB and its associated signaling pathways have been the focus of research in the development of therapeutic strategies for various diseases, including cancer and tissue regeneration.
