PDGF RECEPTOR Meaning and
Definition
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PDGF receptor, also known as platelet-derived growth factor receptor, refers to a type of cell surface receptor that binds to the platelet-derived growth factor (PDGF) ligand. PDGF receptors are a family of receptor tyrosine kinases (RTKs), which are enzymes that catalyze the transfer of phosphate groups from ATP to specific tyrosine residues in target proteins. PDGF receptors are involved in various biological processes such as cell growth, division, differentiation, and survival.
There are two types of PDGF receptors known as PDGFR-α and PDGFR-β. These receptors are composed of three main structural components: an extracellular ligand-binding domain, a transmembrane domain, and an intracellular domain with kinase activity. Upon binding to the PDGF ligand, the receptors undergo a conformational change, leading to receptor dimerization and activation of the intracellular kinase domain. This activates a signaling cascade involving phosphorylation of downstream signaling molecules, which ultimately leads to the regulation of cell behavior and gene expression.
PDGF receptors are widely expressed in many different cell types, including smooth muscle cells, fibroblasts, endothelial cells, and various types of stem cells. Dysregulation of PDGF receptor signaling has been implicated in a variety of diseases, including cancer and fibrotic disorders. Consequently, targeting PDGF receptors has been the focus of therapeutic strategies aimed at inhibiting abnormal cell proliferation and promoting tissue repair. Understanding the structure and function of PDGF receptors is crucial for the development of effective treatments targeting these receptors.
Common Misspellings for PDGF RECEPTOR
- odgf receptor
- ldgf receptor
- 0dgf receptor
- psgf receptor
- pxgf receptor
- pcgf receptor
- pfgf receptor
- prgf receptor
- pegf receptor
- pdff receptor
- pdvf receptor
- pdbf receptor
- pdhf receptor
- pdyf receptor
- pdtf receptor
- pdgd receptor
- pdgc receptor
- pdgv receptor
- pdgg receptor
- pdgt receptor
Etymology of PDGF RECEPTOR
The term "PDGF receptor" has its etymology rooted in its scientific context. "PDGF" stands for Platelet-Derived Growth Factor, which is a molecule involved in cell signaling and growth. The term "receptor" refers to a protein molecule that binds to a specific ligand, such as PDGF, and initiates a cellular response.
Therefore, the etymology of "PDGF receptor" can be broken down as follows:
- PDGF: Platelet-Derived Growth Factor
- Receptor: a molecule that binds to ligands and initiates a cellular response
In summary, the term "PDGF receptor" is based on the scientific nature of its function in cellular signaling.
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