PDGFB GENE Meaning and
Definition
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The PDGFB gene, also known as platelet-derived growth factor subunit B, is a gene responsible for encoding a protein called platelet-derived growth factor B chain. PDGF-B is one of the four different chains found in the platelet-derived growth factor family and is crucial for cellular growth and development.
The PDGFB gene is located on human chromosome 22q13.1 and consists of twelve exons. This gene encodes the precursor protein, which is subsequently cleaved to form the active PDGF-B chain. PDGF-B functions as a growth factor that acts on various cell types such as smooth muscle cells, fibroblasts, and certain immune cells.
Through its interactions with specific cell surface receptors, PDGF-B plays a vital role in the regulation of many cellular processes, including cell division, proliferation, and differentiation. It is involved in the development and maintenance of blood vessels, wound healing, tissue repair, and the formation of some tumors. Abnormalities or dysregulation of the PDGFB gene are associated with several diseases, including cancer, particularly glioblastoma and certain types of mesenchymal tumors. Mutations or alterations in the PDGFB gene have also been linked to developmental disorders such as idiopathic basal ganglia calcification and some cases of familial moyamoya disease.
Understanding the functions and dysregulation of the PDGFB gene contributes to the knowledge and potential therapeutic strategies for various diseases and conditions related to abnormal cell growth and angiogenesis.
Common Misspellings for PDGFB GENE
- odgfb gene
- ldgfb gene
- -dgfb gene
- 0dgfb gene
- psgfb gene
- pxgfb gene
- pcgfb gene
- pfgfb gene
- prgfb gene
- pegfb gene
- pdffb gene
- pdvfb gene
- pdbfb gene
- pdhfb gene
- pdyfb gene
- pdtfb gene
- pdgdb gene
- pdgcb gene
- pdgvb gene
- pdggb gene
Etymology of PDGFB GENE
The etymology of the term "PDGFB gene" can be explained by breaking down the components:
1. PDGF: PDGF stands for "Platelet-Derived Growth Factor". It is a protein that plays a crucial role in cell growth and division, as well as wound healing. The term "platelet-derived" indicates that it is derived or produced by platelets, a type of blood cell involved in clotting.
2. B: The letter "B" in "PDGFB" refers to one of the different forms or isoforms of PDGF. In total, there are four PDGF isoforms, namely PDGF-A, PDGF-B, PDGF-C, and PDGF-D, each encoded by a specific gene.
3. Gene: The term "gene" refers to a unit of hereditary information that is carried within the DNA of living organisms.
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