Neutrophilic eccrine hidradenitides (NEH) refers to a group of rare skin disorders characterized by inflammation and dysfunction of the eccrine sweat glands. The term "neutrophilic" indicates the predominant type of immune cell involved in the inflammatory process, namely neutrophils. Eccrine hidradenitides refer to the inflammation of the sweat glands, which are responsible for producing sweat to regulate body temperature.
NEH typically presents as painful nodules or abscesses in areas of the body with high concentrations of sweat glands, such as the armpits, groin, or perianal region. The condition may lead to the formation of draining sinuses or fistulas, creating open wounds that can be prone to infection. Patients may also experience symptoms like fever, fatigue, and malaise.
The exact cause of NEH is still unknown, although it is believed to be associated with certain underlying conditions, such as autoimmune diseases, infections, or malignancies. Diagnosis is based on clinical presentation, biopsy, and histopathological examination of the affected skin lesions.
Treatment of NEH typically involves addressing the underlying cause, when identified, and managing the symptoms. This may involve the use of anti-inflammatory medications, antibiotics to treat infections, and surgical intervention when necessary. It is important to note that NEH is a chronic condition that can have a significant impact on a patient's quality of life, requiring ongoing management and support.
