Kininase II inhibitors are a class of drugs that regulate the activity of an enzyme called kininase II or angiotensin-converting enzyme (ACE). ACE is primarily involved in the renin-angiotensin-aldosterone system, which helps regulate blood pressure and fluid balance in the body.
These inhibitors work by blocking the action of kininase II or ACE, thus preventing the conversion of angiotensin I into angiotensin II. Angiotensin II is a potent vasoconstrictor that causes blood vessels to narrow, increasing blood pressure. Therefore, by inhibiting ACE, kininase II inhibitors help relax and widen the blood vessels, resulting in lowered blood pressure.
Apart from their anti-hypertensive effects, kininase II inhibitors also have other potential benefits. They may enhance the production of bradykinin, a peptide that promotes vasodilation, and this can further contribute to the reduction of blood pressure. Additionally, kininase II inhibitors may have direct effects on blood vessel remodeling and inflammation, which can be beneficial in various cardiovascular conditions.
These inhibitors are commonly used for the treatment of hypertension or high blood pressure. They may be prescribed alone or in combination with other medications, such as diuretics. Kininase II inhibitors are available in oral forms and are generally well-tolerated, although they can sometimes cause adverse effects like a dry cough, dizziness, or skin rashes.
In summary, kininase II inhibitors are drugs that block the action of an enzyme called kininase II or ACE, resulting in relaxation and widening of blood vessels, thus lowering blood pressure. They are primarily used for treating hypertension and have potential additional benefits in cardiovascular conditions.
