Kininase II antagonists, also known as angiotensin-converting enzyme (ACE) inhibitors, are a class of medications used mainly for the treatment of hypertension (high blood pressure), heart failure, and certain kidney conditions. These drugs are designed to inhibit the action of the enzyme kininase II, also known as ACE.
Kininase II is an enzyme that plays a crucial role in the regulation of blood pressure and fluid balance within the body. It converts angiotensin I, a hormone produced by the body, into angiotensin II, a potent vasoconstrictor that causes blood vessels to narrow. By blocking the action of kininase II, ACE inhibitors prevent the formation of angiotensin II, leading to vasodilation (widening of blood vessels) and a subsequent decrease in blood pressure.
In addition to their blood pressure-lowering effects, kininase II antagonists also inhibit the degradation of bradykinin, a powerful vasodilator and anti-inflammatory substance. This results in increased levels of bradykinin within the body, which further promotes vasodilation and reduces inflammation.
Some commonly prescribed kininase II antagonists include ramipril, lisinopril, enalapril, and captopril. These drugs are typically taken orally, either once or twice daily, as per the instructions of a healthcare professional. While generally safe and well-tolerated, they can occasionally cause side effects such as dry cough, dizziness, and skin rashes.
Overall, kininase II antagonists are valuable medications for managing hypertension and heart failure, and their ability to reduce blood pressure and improve fluid balance makes them an important tool in the treatment of various cardiovascular and renal conditions.
