KALLIDINOGENASE Meaning and
Definition
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Kallidinogenase, also known as kallikrein, is an enzyme that plays a crucial role in the kinin-kallikrein system. It is a protease that can specifically cleave kininogens, resulting in the formation of potent vasodilator peptides known as kinins. This enzyme is primarily found in various tissues, including the salivary glands, kidneys, and pancreas.
The main function of kallidinogenase is to convert kininogens, which are large precursor proteins, into active kinins. Kinins, such as bradykinin and kallidin, act as mediators of inflammation and have important physiological effects on the cardiovascular, renal, and immune systems. Once released, kinins bind to specific receptors, activating a signaling cascade that ultimately leads to vasodilation, increased vascular permeability, smooth muscle contraction, and pain sensation.
Kallidinogenase has been widely used in clinical settings for its therapeutic benefits. Due to its vasodilatory properties, it is often used to treat cardiovascular conditions like hypertension, angina, and peripheral vascular diseases. Additionally, it has shown potential in the treatment of diabetic microangiopathy, renal insufficiency, and edema following surgery.
It is important to note that the use of kallidinogenase as a medication should be done under medical supervision and with the appropriate dosage, as excessive kinin release can lead to adverse effects such as hypotension, edema, and allergic reactions.
In conclusion, kallidinogenase is an enzyme that converts kininogens into vasodilator peptides known as kinins. It plays a significant role in the kinin-kallikrein system and has therapeutic applications in various
Common Misspellings for KALLIDINOGENASE
- jallidinogenase
- mallidinogenase
- lallidinogenase
- oallidinogenase
- iallidinogenase
- kzllidinogenase
- ksllidinogenase
- kwllidinogenase
- kqllidinogenase
- kaklidinogenase
- kaplidinogenase
- kaolidinogenase
- kalkidinogenase
- kalpidinogenase
- kaloidinogenase
- kalludinogenase
- kalljdinogenase
- kallkdinogenase
- kallodinogenase
- kall9dinogenase
Etymology of KALLIDINOGENASE
The word "Kallidinogenase" is derived from two main components: "kallidin" and "genase".
1. Kallidin: The term "kallidin" refers to a peptide that is produced by the action of an enzyme called kallikrein on a precursor protein called kininogen. Initially, the term "kallidin" was coined by combining the name of the enzyme "kallikrein" and the suffix "-idin", which is often used to label peptide substances.
2. -genase: The suffix "-genase" is commonly used in biology and biochemistry to refer to enzymes that generate or produce a specific substance. It comes from the Greek word "gennan", meaning "to produce" or "to generate".
