KALLIKREIN A Meaning and
Definition
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Kallikrein A refers to a group of enzymes known as serine proteases that are encoded by the KLK1 gene in humans. These enzymes are primarily found in the kidneys and are involved in the regulation of blood pressure, fluid and electrolyte balance, as well as inflammatory responses. Kallikrein A enzymes are part of the larger kallikrein family, which includes other closely related enzymes.
The primary function of kallikrein A enzymes is the conversion of kininogen into bradykinin, a potent vasodilator, and mediator of inflammation. Bradykinin plays a crucial role in regulating blood pressure by causing blood vessels to dilate, which helps to lower blood pressure. Additionally, bradykinin promotes the release of prostaglandins and nitric oxide, which further contribute to vasodilation and anti-inflammatory effects.
In clinical settings, kallikrein A levels can be used as biomarkers for certain medical conditions. For example, elevated levels of kallikrein A have been observed in patients with renal diseases such as acute kidney injury and chronic kidney disease. Monitoring kallikrein A levels can aid in the diagnosis and management of these conditions.
In summary, kallikrein A is a group of enzymes involved in the regulation of blood pressure, fluid balance, and inflammatory responses. They play a crucial role in converting kininogen to bradykinin, a potent vasodilator and mediator of inflammation. Understanding the functions and clinical significance of kallikrein A enzymes contributes to our knowledge of various physiological and pathological processes.
Common Misspellings for KALLIKREIN A
