IMMUNOMAGNETIC SEPARATION Meaning and
Definition
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Immunomagnetic separation (IMS), also known as magnetic cell separation or magnetic immunoseparation, is a laboratory technique used to separate specific cells or particles from a complex mixture based on their specific immunologic characteristics. It utilizes magnetic beads coated with antibodies or ligands that can selectively bind to the target cell or particle of interest.
The process begins by incubating the mixture with magnetic beads that have been conjugated with specific antibodies or ligands. These antibodies or ligands recognize and bind to the specific antigen or molecule on the surface of the target cells or particles. Once the binding occurs, a magnetic field is applied, causing the magnetic beads to separate from the rest of the mixture, taking along the target cells or particles with them.
Immunomagnetic separation offers several advantages over other separation techniques. Firstly, it allows for the specific isolation of target cells or particles, while leaving other unwanted components behind. Secondly, it provides a rapid and efficient method for separation, often requiring just a few minutes to complete. Additionally, IMS is a gentle technique that does not harm the isolated cells or particles, making it suitable for further downstream analysis and applications.
The application of immunomagnetic separation is diverse and extensive. It is commonly used in clinical laboratories and research settings for the isolation and detection of rare cells, such as circulating tumor cells, stem cells, and pathogens. It also finds applications in biotechnology, diagnostics, and drug discovery, where the targeted separation and analysis of specific cells or particles are crucial for further characterization and development of therapeutic strategies.
Common Misspellings for IMMUNOMAGNETIC SEPARATION
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Etymology of IMMUNOMAGNETIC SEPARATION
The word "Immunomagnetic Separation" is a technical term in the field of biology and refers to a technique used to separate or isolate specific cells or molecules based on their properties, using magnetic beads conjugated with specific antibodies.
The etymology of the word can be broken down as follows:
1. Immuno-: This prefix is derived from the word "immune" and comes from the Latin word "immunis" meaning "exempt" or "free from". In the context of immunomagnetic separation, it refers to the utilization of antibodies and the immune system to selectively bind and capture target cells or molecules.
2. Magnetic: This term comes from the Greek word "magnēs" meaning "stone of Magnesia". It refers to a naturally occurring mineral called magnetite (Fe3O4), which possesses magnetic properties.
