Graft vs Tumor Response refers to the immune response in which transplanted or grafted tissues or cells recognize and attack tumor cells in the recipient's body. It is a phenomenon observed in the field of transplantation medicine and immunology.
When a graft, such as an organ or tissue, is transplanted into a recipient, it contains immune cells that can recognize and eliminate foreign cells, including tumor cells. This recognition occurs through the interaction between specific proteins on the surface of immune cells, known as T-cells, and antigens present on tumor cells. These antigens, often derived from mutated or abnormal proteins, are recognized as foreign by the immune system.
The graft vs tumor response is triggered when the transplanted immune cells recognize these tumor antigens. These immune cells then mount an attack against the tumor cells, leading to their destruction. This immune response can help in preventing the growth and spread of tumors in the recipient's body.
The graft vs tumor response is a significant aspect of immunotherapy, which aims to harness the body's own immune system to fight cancer. By transplanting immune cells or stimulating their activity, researchers and medical practitioners attempt to enhance the graft vs tumor response and improve the outcomes of cancer treatments.
Overall, the graft vs tumor response exemplifies the complex interactions between the immune system and cancer cells, providing insights into the potential use of immunotherapy for cancer treatment.
