GLUTAMATE DEHYDROGENASE Meaning and
Definition
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Glutamate Dehydrogenase (GDH) is an enzyme that plays a key role in cellular metabolism by catalyzing the conversion of glutamate to alpha-ketoglutarate, along with the reduction of either NAD+ or NADP+. This reaction is part of the larger process called the TCA cycle or Krebs cycle, which is central to generating energy in living organisms.
GDH is found in both prokaryotes and eukaryotes, including bacteria, archaea, plants, animals, and humans. It is particularly abundant in the liver and kidneys. In humans, there are two isoforms of GDH, namely GDH1 and GDH2, with slightly different properties and functions.
In addition to its role in energy production, GDH also plays a regulatory role in some organisms. In bacteria, for instance, it is involved in the assimilation of nitrogen into amino acids, facilitating the conversion of ammonia into glutamate. This process is essential for the synthesis of proteins and many other important molecules.
The activity of GDH is tightly regulated through various mechanisms, such as allosteric regulation and post-translational modifications. Allosteric regulators, such as certain amino acids and nucleotides, can activate or inhibit the activity of GDH depending on the cellular needs. Post-translational modifications, like phosphorylation, can also modulate its activity.
Due to its critical involvement in cellular metabolism, GDH is a subject of scientific interest and has implications in various fields, including biochemistry, cell biology, and medical research. Understanding the function and regulation of GDH can provide insights into cellular metabolism and potential therapeutic targets for metabolic disorders.
Common Misspellings for GLUTAMATE DEHYDROGENASE
- flutamate dehydrogenase
- vlutamate dehydrogenase
- blutamate dehydrogenase
- hlutamate dehydrogenase
- ylutamate dehydrogenase
- tlutamate dehydrogenase
- gkutamate dehydrogenase
- gputamate dehydrogenase
- goutamate dehydrogenase
- glytamate dehydrogenase
- glhtamate dehydrogenase
- gljtamate dehydrogenase
- glitamate dehydrogenase
- gl8tamate dehydrogenase
- gl7tamate dehydrogenase
- gluramate dehydrogenase
- glufamate dehydrogenase
- glugamate dehydrogenase
- gluyamate dehydrogenase
- glu6amate dehydrogenase
Etymology of GLUTAMATE DEHYDROGENASE
The word "Glutamate Dehydrogenase" is a scientific term composed of two main parts: "glutamate" and "dehydrogenase".
1. Glutamate:
- The term "glutamate" comes from the Latin word "gluten", which means "glue" or "gluey substance".
- The suffix "-ate" indicates that it is an anion or a salt derived from an acid. In this case, glutamate is the anion of glutamic acid.
- Glutamate is an amino acid that plays a crucial role in the metabolism of proteins as well as in the function of the nervous system.
2. Dehydrogenase:
- The term "dehydrogenase" is a combination of the prefix "de-" meaning "remove" or "undo", and the word "hydrogen", which refers to the element hydrogen.
