How Do You Spell GLUTAMATE CYSTEINE LIGASE?

Pronunciation: [ɡlˈuːtɐmˌe͡ɪt sˈɪsta͡ɪn lˈɪɡe͡ɪs] (IPA)

The word "Glutamate Cysteine Ligase" is spelled as /ɡluːtəmeɪt ˈsɪstiːn ˈlaɪɡeɪz/ in the International Phonetic Alphabet (IPA) transcription. The first syllable "Glu" is pronounced as "gloo", the second syllable "ta" as "tah", and "mate" as "mayt". The following word "Cysteine" is pronounced as "siss-teen" while "Ligase" is pronounced as "lie-gace". The word refers to an important enzyme responsible for the biosynthesis of glutathione and is widely studied in the field of biochemistry.

GLUTAMATE CYSTEINE LIGASE Meaning and Definition

1. Glutamate Cysteine Ligase, also known as gamma-glutamylcysteine synthetase (GCS), is a key enzyme involved in the synthesis of the tripeptide molecule called glutathione. It is composed of two subunits: the catalytic subunit (GCLC) and the modifier subunit (GCLM).

   Glutathione is an important antioxidant molecule found in cells, tissues, and bodily fluids. Its main function is to protect cells and tissues from oxidative stress by neutralizing harmful free radicals and reactive oxygen species. Glutamate Cysteine Ligase plays a crucial role in the first step of glutathione biosynthesis.

   The enzyme functions by catalyzing the formation of gamma-glutamylcysteine from glutamate and cysteine. Glutamate serves as the donor of the gamma-glutamyl group, while cysteine acts as the acceptor molecule. The reaction is driven by the hydrolysis of ATP (adenosine triphosphate) to ADP (adenosine diphosphate), providing the necessary energy for the synthesis reaction.

   Glutamate Cysteine Ligase is highly regulated and sensitive to changes in cellular redox status. It is transcriptionally regulated by the antioxidant response element (ARE) in the promoter region, which is activated by the transcription factor called NF-E2-related factor 2 (Nrf2). The upregulation of Glutamate Cysteine Ligase leads to an increase in the intracellular concentration of glutathione, resulting in enhanced cellular antioxidant defenses.

   Overall, Glutamate Cysteine Ligase is a crucial enzyme involved in the synthesis of glutathione, contributing to the cellular antioxidant

Common Misspellings for GLUTAMATE CYSTEINE LIGASE

• flutamate cysteine ligase
• vlutamate cysteine ligase
• blutamate cysteine ligase
• hlutamate cysteine ligase
• ylutamate cysteine ligase
• tlutamate cysteine ligase
• gkutamate cysteine ligase
• gputamate cysteine ligase
• goutamate cysteine ligase
• glytamate cysteine ligase
• glhtamate cysteine ligase
• gljtamate cysteine ligase
• glitamate cysteine ligase
• gl8tamate cysteine ligase
• gl7tamate cysteine ligase
• gluramate cysteine ligase
• glufamate cysteine ligase
• glugamate cysteine ligase
• gluyamate cysteine ligase
• glu6amate cysteine ligase