GLUCOSE CLAMPING Meaning and
Definition
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Glucose clamping refers to a laboratory technique used to maintain a constant and controlled level of blood glucose concentration in experimental animals, typically during research studies related to diabetes. It involves the continuous monitoring and adjustment of glucose levels to a desired target value.
In glucose clamping, a glucose infusion is administered directly into the bloodstream to maintain a constant concentration of glucose. This infusion is often achieved using an intravenous catheter placed in a major blood vessel, such as a vein. Simultaneously, blood samples are collected at regular intervals to measure the actual glucose concentration, allowing adjustments to the infusion rate as needed.
The primary objective of glucose clamping is to minimize fluctuations in blood glucose levels, effectively creating a stable and precisely controlled environment for experimental purposes. By maintaining a constant glucose concentration, researchers can investigate the effects of specific interventions or treatments on glucose metabolism without the confounding influence of fluctuating blood sugar levels.
Glucose clamping is particularly useful in studying insulin sensitivity, as it allows researchers to evaluate the impact of various factors on glucose regulation and insulin action independently. It aids in understanding the mechanisms involved in glucose metabolism and can help identify potential therapeutic targets for conditions like diabetes mellitus.
Overall, glucose clamping provides a standardized and reproducible method of investigating the physiological changes associated with glucose regulation, offering valuable insights into the role of glucose homeostasis in health and disease.
Common Misspellings for GLUCOSE CLAMPING
- flucose clamping
- vlucose clamping
- blucose clamping
- hlucose clamping
- ylucose clamping
- tlucose clamping
- gkucose clamping
- gpucose clamping
- goucose clamping
- glycose clamping
- glhcose clamping
- gljcose clamping
- glicose clamping
- gl8cose clamping
- gl7cose clamping
- gluxose clamping
- gluvose clamping
- glufose clamping
- gludose clamping
- glucise clamping
Etymology of GLUCOSE CLAMPING
The term "glucose clamping" originated from the field of medical research, specifically in the study of metabolic regulation and diabetes. Although the word "clamping" has a more general meaning of fastening or securing something tightly, in the context of glucose, the term refers to the tight control or regulation of blood glucose levels.
The etymology breaks down as follows:
1. Glucose: The word "glucose" has its origins in the Greek word "glukus" meaning sweet. It was coined by the French chemist Étienne-François Geoffroy in 1747.
2. Clamping: The word "clamp" originates from the Middle Dutch word "klampe" meaning a hook or a clamp used to hold something tightly. It later came to English from the Old Norse word "klompr", meaning to grasp or hold tightly.
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