How Do You Spell GLUCOSE CLAMP TECHNIQUE?

Pronunciation: [ɡlˈuːkə͡ʊs klˈamp tɛknˈiːk] (IPA)

The Glucose Clamp Technique is a procedure used to measure insulin sensitivity in human subjects. It involves the infusion of glucose and insulin at a constant rate, while blood sugar levels are monitored. The word "glucose" is pronounced ˈɡluːkəʊs, with the stress on the first syllable, and the "e" at the end is silent. "Clamp" is pronounced klæmp, with the stress on the first syllable. The technique is a valuable tool for studying diabetes and other metabolic disorders.

GLUCOSE CLAMP TECHNIQUE Meaning and Definition

1. The glucose clamp technique is a laboratory procedure used in medical research to maintain a constant level of glucose in the bloodstream. It is commonly employed in studies related to diabetes mellitus, metabolic disorders, and the effects of certain drugs on glucose regulation. The procedure involves the infusion of glucose into the bloodstream at a constant rate, while glucose levels are continuously measured and adjusted to maintain a stable concentration.

   During a glucose clamp experiment, a subject is typically connected to an intravenous line, which allows precise control of the glucose infusion. Blood samples are taken at regular intervals to monitor the glucose concentration in the bloodstream. If the glucose level deviates from the desired target, adjustments are made to the infusion rate to maintain stability. Typically, this is achieved using a feedback control algorithm that calculates the necessary adjustments based on the observed blood glucose levels.

   The glucose clamp technique provides researchers with a way to assess the effects of various interventions on glucose regulation. By maintaining a steady glucose concentration, it is possible to study the function of insulin and other hormones involved in glucose metabolism, as well as evaluate the efficacy of new drugs designed to improve glucose control. Additionally, the glucose clamp technique allows for a more precise determination of insulin sensitivity, which is a critical parameter in the evaluation of individuals with diabetes or other metabolic disorders.

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