CDNA LIBRARY Meaning and
Definition
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A cDNA library, also known as a complementary DNA library, is a collection of complementary DNA molecules representing the entire set of genes of an organism, cell type, or tissue. It is constructed by synthesizing and cloning complementary DNA (cDNA) molecules derived from messenger RNA (mRNA), which carries the genetic information from the DNA to the ribosomes for protein synthesis.
The process involves the conversion of the mRNA into cDNA using an enzyme called reverse transcriptase. Reverse transcription allows the synthesis of cDNA using the mRNA template, resulting in a collection of single-stranded cDNA molecules that represent the genes expressed in the original sample. The cDNA molecules are then transformed into a suitable bacterial host using a plasmid or phage vector for cloning purposes.
cDNA libraries are valuable tools in molecular biology and genomics research as they provide a comprehensive representation of the genes that are active at a particular time or under specific conditions. They enable the study of gene expression, identification of specific mRNA sequences through hybridization techniques, and the cloning and expression of specific genes. cDNA libraries have proven instrumental in various applications, including the study of gene function, disease research, drug discovery, and development of genetically modified organisms (GMOs).
In summary, a cDNA library is a collection of cloned cDNA molecules that represent the genes expressed in a specific cell type or tissue at a given time. It serves as a resource for studying gene expression and function, and plays a crucial role in various fields of biological research.
Common Misspellings for CDNA LIBRARY
- xdna library
- vdna library
- fdna library
- ddna library
- csna library
- cxna library
- ccna library
- cfna library
- crna library
- cena library
- cdba library
- cdma library
- cdja library
- cdha library
- cdnz library
- cdns library
- cdnw library
- cdnq library
- cdna kibrary
- cdna pibrary
Etymology of CDNA LIBRARY
The word "cDNA library" is derived from two key terms: cDNA and library.
1. cDNA: cDNA stands for complementary DNA. It is a synthesized DNA molecule that is reverse transcribed from a messenger RNA (mRNA) template. The "c" in cDNA indicates that it is a complementary copy of the original mRNA.
2. Library: In a scientific context, a library refers to a collection or catalog of various components, usually organized in a systematic manner. In the case of cDNA library, it refers to a collection of cloned cDNA fragments that represent the entire set of expressed genes in an organism.
Therefore, the etymology of the term "cDNA library" combines the concept of complementary DNA (cDNA) and the idea of a comprehensive collection (library) of cloned cDNA fragments.
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