How Do You Spell TOTAL HEMOLYTIC COMPLEMENT?

Pronunciation: [tˈə͡ʊtə͡l hˌiːməlˈɪtɪk kˈɒmplɪmənt] (IPA)

Total Hemolytic Complement is a term used in immunology to describe a set of proteins that can destroy pathogens. The word "hemolytic" refers to its destructive capacity, while "complement" refers to its ability to enhance the immune response. The IPA phonetic transcription of this term is /ˈtoʊ.təl ˌhiː.məˈlɪtɪk ˈkɒmplɪmənt/, where the stressed syllables are marked with an apostrophe. The terms may appear complex, but the use of phonetics and proper jargon can help ensure proper understanding and communication among researchers and practitioners in the field.

TOTAL HEMOLYTIC COMPLEMENT Meaning and Definition

1. Total Hemolytic Complement (THC) is a laboratory measurement used to assess the activity and quantity of the complement system in the blood. The complement system is a group of proteins present in the blood that plays a crucial role in the immune response against foreign invaders, such as bacteria and viruses.

   The THC test measures the ability of the complement system to cause the destruction (lysis) of red blood cells in the presence of a specific substance called sheep red blood cells (SRBCs) and a complement-activating substance. The compliment-activating substance, usually antibody or heat-aggregated IgG, triggers the activation of the complement cascade, resulting in the formation of a membrane attack complex (MAC) that causes the lysis of the red blood cells.

   The THC value is reported as the highest dilution of the patient's serum that causes 50% lysis of the SRBCs. It is expressed as a numerical value representing the serum dilution, such as 1:32 or 1:64. A higher THC value indicates a higher level of complement activity.

   The THC test is commonly used in the diagnosis and monitoring of certain autoimmune disorders, such as systemic lupus erythematosus (SLE), where complement deficiencies or abnormalities are observed. Abnormal THC levels can also be indicative of certain infections, inflammatory diseases, or inherited complement deficiencies.

   Overall, the THC test provides valuable information about the functional status and quantity of the complement system, aiding in the diagnosis and monitoring of various immune-related conditions.

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