THROMBOKINASE Meaning and
Definition
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Thrombokinase, also known as tissue factor or factor III, is a key component involved in the coagulation cascade, which is the process that leads to the formation of blood clots. It is an enzyme that triggers the activation of the coagulation pathway and initiates the formation of a fibrin clot to stop bleeding.
Thrombokinase is normally present in the subendothelial tissues and is released upon injury or damage to the blood vessels. It plays a crucial role in the extrinsic pathway of coagulation. Once released, thrombokinase binds with factor VII, a vitamin K-dependent clotting factor, to form a complex. This complex then activates factors IX and X, which are essential for the conversion of prothrombin to thrombin. Thrombin, in turn, catalyzes the conversion of fibrinogen to fibrin, which forms a mesh-like structure that stabilizes the blood clot.
The presence of thrombokinase is crucial for the initiation of the coagulation cascade as it provides the starting point for the formation of a clot. Without thrombokinase, blood clotting would be impaired, leading to prolonged bleeding and potentially life-threatening situations.
Overall, thrombokinase is an enzyme released from damaged tissues that plays a vital role in the clotting process. Its activation triggers a series of biochemical reactions leading to the formation of blood clots, which is essential in preventing excessive bleeding and maintaining hemostasis.
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A zymoplastic substance contained in the tissues and the blood, which is supposed to possess the property of activating thrombogen when combined with a calcium salt.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for THROMBOKINASE
- rhrombokinase
- fhrombokinase
- ghrombokinase
- yhrombokinase
- 6hrombokinase
- 5hrombokinase
- tgrombokinase
- tbrombokinase
- tnrombokinase
- tjrombokinase
- turombokinase
- tyrombokinase
- theombokinase
- thdombokinase
- thfombokinase
- thtombokinase
- th5ombokinase
- th4ombokinase
- thrimbokinase
Etymology of THROMBOKINASE
The word "thrombokinase" is derived from two components: "thrombo-" and "-kinase".
1. "Thrombo-" is a combining form derived from the Greek word "thrombos", meaning "clot" or "clumping of blood". This is related to the medical term "thrombosis", which refers to the formation of a blood clot within a blood vessel.
2. "-Kinase" is a suffix derived from the Greek word "kīnēsis", meaning "movement" or "motion". In medical terminology, "-kinase" is often used to denote an enzyme that promotes a specific biochemical reaction or process.
Therefore, "thrombokinase" refers to an enzyme involved in the clotting process, specifically the conversion of prothrombin to thrombin during blood coagulation.
Similar spelling words for THROMBOKINASE
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