The spelling of the word "syphylopathy" may appear confusing at first glance, but it can be deciphered using the International Phonetic Alphabet (IPA). The correct spelling of the word is actually "syphilopathy". The "y" is replaced with an "i" and the "o" is switched with an "a". The correct pronunciation of the word is /sɪfɪˈlɒpəθi/ (sih-fuh-lop-uh-thee), with the emphasis on the second syllable. Syphilopathy refers to a disease caused by the sexually transmitted infection, syphilis.