SURROGATE MARKERS Meaning and
Definition
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Surrogate markers, also known as surrogate endpoints or biomarkers, are measurable indicators that are used in scientific research or clinical trials as substitutes or proxies for more difficult or less accessible clinical outcomes. These markers are used to predict, monitor, or assess the effects of a specific treatment or intervention on a particular disease or health condition.
Surrogate markers are often used when the direct measurement of clinical endpoints is unfeasible, cumbersome, or time-consuming. They are chosen based on evidence that suggests a strong association between the marker and the actual clinical outcome of interest. This close relationship allows researchers to infer that changes in the surrogate marker will likely correspond to changes in the clinical outcome, making it useful for assessing the efficacy or safety of an intervention more rapidly and efficiently.
Some common examples of surrogate markers include blood pressure, cholesterol levels, tumor size, or specific biomarkers that are indicative of disease progression or response to treatment. These surrogate markers are used in various fields, including pharmaceutical research and development, epidemiology, and public health, to evaluate the effectiveness of new drugs, vaccines, or interventions.
However, it is important to note that surrogate markers are not always accurate predictors of clinical outcomes, and their use should be supported by strong scientific evidence. It is crucial to validate and establish the relationship between the surrogate marker and the clinical endpoint before relying on it to make informed decisions about treatment or intervention outcomes.
Common Misspellings for SURROGATE MARKERS
- aurrogate markers
- zurrogate markers
- xurrogate markers
- durrogate markers
- eurrogate markers
- wurrogate markers
- syrrogate markers
- shrrogate markers
- sjrrogate markers
- sirrogate markers
- s8rrogate markers
- s7rrogate markers
- suerogate markers
- sudrogate markers
- sufrogate markers
- sutrogate markers
- su5rogate markers
- su4rogate markers
- sureogate markers
- surdogate markers
Etymology of SURROGATE MARKERS
The word "surrogate" originates from the Latin word "surrogatus", which means "substitute" or "deputy". It was formed from the prefix "sur-" meaning "sub-" or "under" and the Latin verb "rogare", which means "to ask" or "to request".
The term "marker" is derived from the Middle English word "markere", which came from the Old English word "mearcere", meaning "boundary" or "border". It can also refer to a sign or a distinguishing feature.
When combined, "surrogate markers" refers to substitute indicators or signs that are used in place of specific disease outcomes or endpoints in medical research or clinical trials. These markers are used to provide information about the effectiveness or progression of a disease in place of direct measurements of the disease itself.
