SURROGATE MARKER Meaning and
Definition
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A surrogate marker is a biological or clinical measurement used as a substitute for a clinically meaningful and patient-centered endpoint in medical research or clinical trials. It is used as a tool to assess the efficacy or predict the outcome of a therapeutic intervention or disease progression.
In medical research and drug development, surrogate markers play a fundamental role by providing a measurable and objective endpoint that can be evaluated relatively quickly and efficiently, compared to the primary endpoint which might take longer to observe or might be more challenging to measure accurately. Surrogate markers are often selected based on their known association with the primary endpoint, and are used to provide an indirect but reliable estimation of treatment effects.
Surrogate markers can be both clinical and biochemical measurements. Clinical markers could include blood pressure, heart rate, or disease-specific scoring systems, whereas biochemical markers might involve measuring specific proteins, hormones, or genetic markers in bodily fluids or tissues.
The primary advantage of surrogate markers is their ability to expedite the evaluation of interventions, allowing researchers to make informed decisions about their effectiveness and safety in a shorter period. However, it is important to note that surrogate markers are not always entirely accurate or reliable predictors of clinical outcomes, and their validity needs to be carefully evaluated and validated in each specific context.
Common Misspellings for SURROGATE MARKER
- aurrogate marker
- zurrogate marker
- xurrogate marker
- durrogate marker
- eurrogate marker
- wurrogate marker
- syrrogate marker
- shrrogate marker
- sjrrogate marker
- sirrogate marker
- s8rrogate marker
- s7rrogate marker
- suerogate marker
- sudrogate marker
- sufrogate marker
- sutrogate marker
- su5rogate marker
- su4rogate marker
- sureogate marker
- surdogate marker
Etymology of SURROGATE MARKER
The word "surrogate" is derived from the Latin word "surrogatus", which means "appointed to act in place of another". The term "marker" has its roots in the Old English word "mearcian", which means "to mark or show".
In the context of medicine and scientific research, a "surrogate marker" refers to a variable or measurement that stands as a substitute or proxy for a clinical endpoint or outcome that is impractical to measure directly. The term was first coined in the early 1980s and has become widely used in clinical trials, epidemiology, and other research areas to assess the effectiveness or safety of a medical intervention.
The etymology of "surrogate marker" combines the concept of a substitute or proxy (surrogate) with the idea of showing or indicating (marker).
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