SURROGATE ENDPOINT Meaning and
Definition
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A surrogate endpoint is a measurable or observable variable that is used in medical research or clinical trials as a substitute for a clinical endpoint or outcome. It is generally used to predict or suggest the real clinical benefit of a treatment or intervention without directly measuring the desired outcome.
In biomedical research, clinical trials are often conducted for long durations, require large sample sizes, and incur substantial costs. Surrogate endpoints offer a more convenient and time-saving alternative by providing an indirect measure of treatment effectiveness. These surrogate markers are typically intermediate biomarkers or laboratory measurements that can be easily measured and quantified in a shorter period compared to clinical endpoints.
The use of surrogate endpoints allows researchers to make predictions about the efficacy or safety of a treatment without waiting for the relevant clinical endpoint such as overall survival, disease relapse, or symptom improvement. However, it is important to note that surrogate endpoints do not always reliably correlate with true clinical outcomes, and their validity must be evaluated and validated in each specific context.
The selection of an appropriate surrogate endpoint requires scientific evidence and validation to establish its relevance and association with the desired outcome. Regulatory authorities, such as the U.S. Food and Drug Administration (FDA), evaluate the appropriateness of surrogate endpoints in the approval process of drugs and medical devices.
In summary, surrogate endpoints provide a proxy measurement to estimate treatment effects or outcomes in clinical trials, potentially saving time and resources.
Common Misspellings for SURROGATE ENDPOINT
- aurrogate endpoint
- zurrogate endpoint
- xurrogate endpoint
- durrogate endpoint
- eurrogate endpoint
- wurrogate endpoint
- syrrogate endpoint
- shrrogate endpoint
- sjrrogate endpoint
- sirrogate endpoint
- s8rrogate endpoint
- s7rrogate endpoint
- suerogate endpoint
- sudrogate endpoint
- sufrogate endpoint
- sutrogate endpoint
- su5rogate endpoint
- su4rogate endpoint
- sureogate endpoint
- surdogate endpoint
Etymology of SURROGATE ENDPOINT
The word "Surrogate" originated from the Latin word "surrogatus", which means "substitute". It later evolved in French as "surogat" before entering the English language.
"Endpoint", on the other hand, comes from the combination of two words: "end" and "point". In this context, "endpoint" refers to a measurable outcome used to evaluate the effectiveness of a treatment or intervention.
When combined, the term "Surrogate Endpoint" refers to a substitute or proxy endpoint used in clinical trials or research studies, which may not directly represent the ultimate clinical outcome of interest but can be reasonably expected to predict it.
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