STREPTOGRAMIN A Meaning and
Definition
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Streptogramin A refers to a class of antibiotics derived from natural products originating from Streptomyces bacteria. It is a cyclic peptide antibiotic that exhibits potent antimicrobial activity against various Gram-positive bacteria, particularly those belonging to the genera Staphylococcus, Streptococcus, and Enterococcus.
Streptogramin A exerts its bactericidal effect by targeting the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. It specifically binds to the peptidyl transferase center, interfering with the translocation step of protein synthesis. This disruption prevents the formation of functional proteins necessary for bacterial growth and survival. It has a unique mode of action that distinguishes it from other classes of antibiotics, making it effective against certain multidrug-resistant bacteria.
Streptogramin A antibiotics are commonly used in combination with another streptogramin antibiotic, known as streptogramin B, forming a group called the "streptogramins." This combination, known as a synergistic combination, enhances their antimicrobial activity by targeting different steps in the bacterial protein synthesis pathway. This combination therapy, known as "quinupristin-dalfopristin," has proven effective against drug-resistant strains of bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE).
However, the use of streptogramin A antibiotics can be limited by various factors, including resistance mechanisms that bacteria may develop over time. Despite these limitations, streptogramin A antibiotics remain an important treatment option for certain bacterial infections, especially those caused by multidrug-resistant Gram-positive bacteria.
Common Misspellings for STREPTOGRAMIN A
- atreptogramin a
- ztreptogramin a
- xtreptogramin a
- dtreptogramin a
- etreptogramin a
- wtreptogramin a
- srreptogramin a
- sfreptogramin a
- sgreptogramin a
- syreptogramin a
- s6reptogramin a
- s5reptogramin a
- steeptogramin a
- stdeptogramin a
- stfeptogramin a
- stteptogramin a
- st5eptogramin a
- st4eptogramin a
- strwptogramin a
- strsptogramin a
Etymology of STREPTOGRAMIN A
The word "Streptogramin A" is a scientific term used to describe a specific class of antibiotics.
The term "Streptogramin" comes from the combination of two words: "Strepto" and "gramin".
1. "Strepto" is derived from the root word "Streptos", which originates from the Greek word "streptos" meaning "twisted" or "curved". It refers to the twisted or curved appearance of the Streptomyces bacteria, which are a common source of antibiotics.
2. "Gramin" is derived from the Latin word "gramina", which means "grass". It refers to the grass-like appearance of the colonies of Streptomyces bacteria when grown in culture.
The suffix "in" is often used in scientific nomenclature to indicate a substance or belonging to a specific class or group.
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