SIS GENES Meaning and
Definition
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Sis genes, also known as sister-chromatid cohesion genes, refer to a group of genes that play crucial roles in the maintenance and regulation of chromosomal stability and accurate segregation during cell division. They are responsible for establishing and maintaining physical connections between sister chromatids, which are identical copies of a chromosome resulting from DNA replication. These connections, formed during the S phase of the cell cycle, ensure that sister chromatids remain together until their separation during the later stages of cell division.
Sis genes encode for proteins that are part of the cohesin complex, a protein complex that acts as a molecular glue to hold sister chromatids together. This complex consists of different subunits, including structural maintenance of chromosomes (SMC) proteins and non-SMC proteins. The interaction between cohesin subunits, mediated by sis genes, allows for the establishment of sister-chromatid cohesion.
Mutations or dysregulation of sis genes can lead to disruptions in sister-chromatid cohesion, resulting in chromosomal instability and an increased risk of genetic disorders, including cancers and developmental abnormalities. Defects in sis genes have been identified in various diseases, such as Roberts syndrome and Cornelia de Lange syndrome.
Understanding the functions and mechanisms of sis genes is essential for elucidating the molecular basis of chromosome dynamics, DNA repair, and accurate chromosome segregation, with potential implications for human health and disease.
Common Misspellings for SIS GENES
- ais genes
- zis genes
- xis genes
- dis genes
- eis genes
- wis genes
- sus genes
- sjs genes
- sks genes
- sos genes
- s9s genes
- s8s genes
- sia genes
- siz genes
- six genes
- sid genes
- sie genes
- siw genes
- sis fenes
- sis venes
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