PENICILLIN AMIDOHYDROLASE Meaning and
Definition
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Penicillin Amidohydrolase, also known as penicillinase or beta-lactamase, is an enzyme that plays a significant role in antibiotic resistance. It is produced by certain bacteria and is capable of breaking down and deactivating penicillin, rendering it ineffective in inhibiting bacterial growth.
The mechanism of action of penicillin amidohydrolase involves hydrolyzing the beta-lactam ring present in penicillin-based antibiotics. This ring is a crucial structural component responsible for the antibiotic's ability to inhibit the synthesis of bacterial cell walls. By cleaving this ring, penicillin amidohydrolase disrupts the antibiotic's mechanism, preventing it from binding to the target site and inhibiting bacterial growth.
The production of penicillin amidohydrolase by bacteria is an adaptive response to protect themselves from the effects of penicillin. This enzyme provides resistance against various types of penicillin-based antibiotics, including penicillin G, ampicillin, and amoxicillin. Bacteria that produce penicillin amidohydrolase are commonly associated with infections that are difficult to treat with penicillin antibiotics due to their resistance.
The discovery and understanding of penicillin amidohydrolase have contributed to the development of alternative antibiotics in the face of antibiotic resistance. Scientists have focused on developing beta-lactamase inhibitors to counteract the effects of this enzyme and restore the effectiveness of penicillin-based antibiotics. Additionally, the study of penicillin amidohydrolase has also led to the creation of modified penicillin derivatives that can evade its effects and provide a viable treatment option for infections caused by bacteria with penicillinase production.
Common Misspellings for PENICILLIN AMIDOHYDROLASE
- oenicillin amidohydrolase
- lenicillin amidohydrolase
- -enicillin amidohydrolase
- 0enicillin amidohydrolase
- pwnicillin amidohydrolase
- psnicillin amidohydrolase
- pdnicillin amidohydrolase
- prnicillin amidohydrolase
- p4nicillin amidohydrolase
- p3nicillin amidohydrolase
- pebicillin amidohydrolase
- pemicillin amidohydrolase
- pejicillin amidohydrolase
- pehicillin amidohydrolase
- penucillin amidohydrolase
- penjcillin amidohydrolase
- penkcillin amidohydrolase
- penocillin amidohydrolase
- pen9cillin amidohydrolase
- pen8cillin amidohydrolase
Etymology of PENICILLIN AMIDOHYDROLASE
The term "penicillin amidohydrolase" is derived from a combination of words, each with its own etymology:
1. Penicillin: The word "penicillin" comes from the genus name of the fungus Penicillium, which was first isolated by Scottish biologist Alexander Fleming in 1928. The name "penicillin" originally referred to a particular antibiotic produced by this fungus.
2. Amidohydrolase: "Amidohydrolase" is a combination of two terms: "amido" and "hydrolase".
- Amido: The term "amido" comes from the Greek word "amidion", meaning "starch". In chemistry, "amido" refers to a functional group containing a carbonyl group (C=O) and an amino group (NH2).
