PDZ Meaning and
Definition
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PDZ, short for PSD-95/Discs large/ZO-1, is a protein domain involved in cell signaling and protein-protein interactions. It is named after the three proteins PSD-95, Discs large, and ZO-1, where it was first identified. The PDZ domain is found in a wide variety of cellular proteins and serves as a crucial component in the assembly of protein complexes at specialized cell junctions and signaling complexes.
The PDZ domain consists of approximately 90-100 amino acids that form a compact globular structure. Its primary function is to bind to specific peptide sequences located at the C-terminus of target proteins. This interaction is mediated by a conserved binding groove within the PDZ domain that recognizes short peptide motifs. Consequently, PDZ domains often act as scaffolding modules, facilitating the assembly of large protein complexes involved in diverse cellular processes such as cell adhesion, synaptic transmission, and intracellular signaling.
In addition to C-terminus interactions, PDZ domains can also engage in homo- and hetero-dimerization, further enhancing their versatility in mediating protein-protein interactions. These interactions can modulate the activity and localization of target proteins, influencing various signaling pathways and cellular functions.
Overall, the PDZ domain plays a fundamental role in protein trafficking, signal transduction, and cellular organization. Its wide distribution and versatility make PDZ domains essential components in maintaining cellular homeostasis and proper functioning.
Common Misspellings for PDZ
- pldz
- p-dz
- 0pdz
- p0dz
- pxdz
- pddz
- pdzz
- pd z
- pdzia
- pdtz
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