MOLONEY MURINE SARCOMA VIRUS Meaning and
Definition
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Moloney murine sarcoma virus (Mo-MuSV) is a type of retrovirus that primarily infects mice and has been widely studied as a model for understanding cancer development and genetic manipulation in animal models.
Mo-MuSV belongs to the class of oncoviruses, which are viruses that have the potential to cause cancer. It was first discovered in the mid-1960s in a mouse sarcoma tumor. The virus induces the formation of tumors, particularly fibrosarcomas, by altering the genetic material of cells it infects.
The genome of Mo-MuSV consists of a single-stranded RNA molecule that is reverse transcribed into DNA upon entering the host cell. This DNA is then integrated into the host genome, leading to the expression of viral genes and disruption of normal cellular processes.
One of the key features of Mo-MuSV is its ability to transform normal cells into cancerous cells. This transformation is mainly mediated by the viral oncogene v-src, which is responsible for the abnormal cell growth and division seen in infected cells. The v-src protein produced by Mo-MuSV acts as a potent tyrosine kinase, causing uncontrolled cell proliferation and promoting tumor formation.
Mo-MuSV has been instrumental in advancing our understanding of oncogenes and cancer biology. Studies using Mo-MuSV as a model have contributed greatly to the development of gene therapy approaches and the identification of novel therapeutic targets for various types of cancers.
Common Misspellings for MOLONEY MURINE SARCOMA VIRUS
- noloney murine sarcoma virus
- koloney murine sarcoma virus
- joloney murine sarcoma virus
- miloney murine sarcoma virus
- mkloney murine sarcoma virus
- mlloney murine sarcoma virus
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- m9loney murine sarcoma virus
- mokoney murine sarcoma virus
- moponey murine sarcoma virus
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- molkney murine sarcoma virus
- mollney murine sarcoma virus
- molpney murine sarcoma virus
- mol0ney murine sarcoma virus
- mol9ney murine sarcoma virus
- molobey murine sarcoma virus
- molomey murine sarcoma virus
