MIXED LYMPHOCYTE CULTURE TEST Meaning and
Definition
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The Mixed Lymphocyte Culture Test (MLC) is an immunological assay used to determine the compatibility and level of immune response between two individuals. It is primarily performed in the field of organ transplantation to assess the degree of similarity or difference in their human leukocyte antigen (HLA) genotypes, which play a crucial role in the acceptance or rejection of transplanted tissues or organs.
During the MLC test, lymphocytes (white blood cells responsible for immune response) from the potential recipient and the donor are mixed together and cultured in a laboratory setting. The mixed lymphocytes are then stimulated to replicate and produce a reaction, which can be visually assessed. The extent of the reaction, indicated by the presence of proliferated cells or other signs of immune response, reflects the degree of HLA compatibility between the two individuals.
If the individuals have a high degree of HLA similarity, the mixed lymphocyte reaction will be minimal, suggesting a low risk of rejection. On the other hand, a strong immune response and increased lymphocyte proliferation indicate a major HLA mismatch, making organ transplantation more challenging.
The Mixed Lymphocyte Culture Test is an essential tool in determining the likelihood of a successful organ transplant by evaluating the compatibility between the donor and the recipient's immune systems. It aids physicians in selecting the most suitable donor for transplantation and implementing appropriate immunosuppressive strategies to mitigate the risk of rejection and improve the overall success rate of organ transplantation.
Common Misspellings for MIXED LYMPHOCYTE CULTURE TEST
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