MIXED LEUKOCYTE CULTURE TEST Meaning and
Definition
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The Mixed Leukocyte Culture Test, also known as MLCT, is a laboratory test used in immunology and transplantation medicine to assess the compatibility and potential immune response between cells from different individuals. Specifically, this test evaluates the compatibility or incompatibility of white blood cells, or leukocytes, between a recipient and a potential donor.
The MLCT involves mixing leukocytes obtained from the donor and recipient individuals and culturing them together in a controlled laboratory environment. By observing the interaction between the two cell populations, this test helps determine the level of compatibility and the potential for immune rejection or compatibility between the individuals.
During the MLCT, if the recipient's immune system recognizes and reacts adversely to the donor's leukocytes, it indicates a higher risk of immune rejection upon transplantation. On the other hand, if the interaction between the cells is harmonious and does not produce a significant immune response, it suggests a greater likelihood of compatibility.
The Mixed Leukocyte Culture Test plays a crucial role in transplant medicine as it helps predict the outcome of transplantation procedures, such as organ or bone marrow transplants, by assisting in the selection of suitable donors. It aids in minimizing the probability of immune rejection and improving graft survival rates by identifying donor-recipient pairs who are more compatible at the cellular level.
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