MIXED LEUKOCYTE REACTIONS Meaning and
Definition
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Mixed leukocyte reactions (MLRs) are in vitro laboratory tests used to assess the compatibility of different immune systems or to evaluate the potential for immunologic reactivity between cells from different individuals. MLRs typically involve the mixing of lymphocytes or leukocytes from two or more individuals to observe the cellular interactions and immune response that ensues.
These reactions are commonly carried out by isolating peripheral blood mononuclear cells from the individuals involved and subsequently mixing equal numbers of cells from each donor. The cells are then cultured together under controlled conditions to allow them to interact. MLRs can also be performed using purified populations of specific immune cell subsets, such as T lymphocytes. Following the mixing and incubation, various readouts can be measured, including cell proliferation, cytokine release, and cytotoxicity.
MLRs are valuable tools in transplantation medicine and immunology research as they provide a means to predict the compatibility or rejection of tissues or organs prior to transplantation. By assessing the degree of lymphocyte activation and proliferation, MLRs can provide insights into the potential for graft-versus-host disease, organ rejection, or other immunological reactions.
Overall, mixed leukocyte reactions enable researchers and clinicians to investigate and understand the complex interactions between immune cells from different individuals, and their outcomes can provide crucial information in the fields of transplantation, immunology, and personalized medicine.
Common Misspellings for MIXED LEUKOCYTE REACTIONS
- nixed leukocyte reactions
- kixed leukocyte reactions
- jixed leukocyte reactions
- muxed leukocyte reactions
- mjxed leukocyte reactions
- mkxed leukocyte reactions
- moxed leukocyte reactions
- m9xed leukocyte reactions
- m8xed leukocyte reactions
- mized leukocyte reactions
- miced leukocyte reactions
- mided leukocyte reactions
- mised leukocyte reactions
- mixwd leukocyte reactions
- mixsd leukocyte reactions
- mixdd leukocyte reactions
- mixrd leukocyte reactions
- mix4d leukocyte reactions
- mix3d leukocyte reactions
- mixes leukocyte reactions
