Mice Pneumonia Virus (MPV) is a highly contagious respiratory disease that primarily affects mice. It is caused by a type of virus called Pneumonia virus of mice (PVM), which belongs to the family Paramyxoviridae. MPV has been observed in laboratory mouse colonies worldwide and is one of the most common viral infections in these animals.
This virus spreads through direct contact with infected mice or their respiratory secretions, as well as through contaminated surfaces or aerosol transmission. It primarily affects the respiratory system of mice, leading to pneumonia, inflammation of the lungs, and respiratory distress. Infected mice may exhibit symptoms such as rapid shallow breathing, reduced activity levels, hunched posture, and weight loss. In severe cases, MPV can cause high rates of morbidity and mortality, particularly in young mice and immunocompromised individuals.
Due to its highly contagious nature, effective management of MPV involves implementing strict biosecurity measures in mouse colonies, such as regular health monitoring, isolation of infected animals, and enhanced cleaning and disinfection protocols. Vaccination against MPV is currently not available, so prevention relies on minimizing exposure and maintaining a hygienic environment for the mice.
Research on MPV primarily focuses on understanding its pathogenesis, transmission dynamics, and development of diagnostic tools. The study of this virus is crucial for ensuring the health and welfare of laboratory mice and the reliability of research outcomes that require the use of these animals.
