MARGINATION Meaning and
Definition
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Margination is a term used in medicine and biology to describe the process of white blood cells, specifically leukocytes, moving from the central bloodstream to the periphery of blood vessels. It is a crucial step in the immune response and inflammation. The migration of leukocytes towards the blood vessel walls is due to the interactions between these cells and the endothelial lining of the blood vessels.
During margination, leukocytes adhere to the endothelial cells lining the blood vessels. This adhesion is facilitated by cell adhesion molecules on the surface of both types of cells. Once leukocytes have adhered to the endothelium, they begin to roll along the blood vessel walls. This rolling motion is assisted by specialized proteins on their surfaces and the presence of chemokines that act as chemoattractants.
The process of margination allows the leukocytes to effectively survey the endothelial lining for signs of infection or tissue damage. If any such indications are detected, the leukocytes can undergo a process known as diapedesis, in which they squeeze between endothelial cells to migrate into the surrounding tissue. Once in the tissue, these immune cells can differentiate, multiply, and initiate a targeted immune response.
Margination is a fundamental mechanism for the recruitment of leukocytes to sites of infection or injury, enabling them to perform their vital immune functions. Understanding the intricate processes involved in margination can help elucidate the underlying mechanisms of inflammation and aid in the development of therapeutic strategies to modulate immune responses.
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The adhesion of the leucocytes to the walls of the blood-vessels in beginning inflammation.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for MARGINATION
- nargination
- kargination
- jargination
- mzrgination
- msrgination
- mwrgination
- mqrgination
- maegination
- madgination
- mafgination
- matgination
- ma5gination
- ma4gination
- marfination
- marvination
- marbination
- marhination
- maryination
- martination
- margunation
Etymology of MARGINATION
The word "margination" is derived from the Latin word "margō", which means "margin" or "border". The suffix "-ation" is added to the root word to form a noun, indicating the action or process of creating a margin or boundary. In the context of "margination", it refers to the act of creating margins or borders around something.
Similar spelling words for MARGINATION
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