Marburg-like viruses are a group of highly infectious and potentially deadly viruses belonging to the Filoviridae family. They are named after the first identified outbreak that occurred in Marburg, Germany in 1967. Marburg-like viruses are closely related to the Ebola virus and share many similarities in terms of disease manifestation and transmission.
These viruses are single-stranded RNA viruses, characterized by their filamentous or thread-like shape, and are classified into two species: Marburg marburgvirus and Ravn marburgvirus. Marburg-like viruses primarily infect humans and nonhuman primates, causing severe and often fatal hemorrhagic fever. The transmission of these viruses primarily occurs through direct contact with bodily fluids, such as blood, feces, or saliva, of infected individuals or animals.
The clinical features of Marburg-like virus infections include a sudden onset of symptoms such as fever, headache, muscle aches, and general malaise. As the disease progresses, it can lead to severe bleeding, organ failure, and ultimately death in many cases. There is currently no specific treatment for Marburg-like virus infections, and management primarily involves supportive care to alleviate symptoms and prevent complications.
Due to their high mortality rate and potential for causing outbreaks, Marburg-like viruses are classified as biosafety level 4 pathogens, requiring strict containment measures in laboratory settings. Outbreaks of Marburg-like virus infections have been infrequent but have occurred in various countries in Africa, including Uganda, Angola, and the Democratic Republic of Congo. Comprehensive surveillance, early detection, and prompt implementation of control measures are crucial in preventing the spread of these dangerous viruses.
