Lupus erythematosus panniculitis, also known as lupus profundus, is a rare and chronic form of cutaneous lupus erythematosus that primarily affects the subcutaneous adipose tissue. It is a localized form of the autoimmune disease lupus erythematosus, which is characterized by inflammation and tissue damage.
Lupus erythematosus panniculitis typically manifests as deep-seated nodules or plaques that are firm, tender, and often purple or red in color. These lesions commonly occur on the face, scalp, upper arms, back, buttocks, and thighs. In some cases, they can ulcerate or become painful. The condition generally occurs in adults, more frequently in women than men.
The exact cause of lupus erythematosus panniculitis is not fully understood, but it is believed to be associated with an autoimmune response. In individuals with this condition, the immune system mistakenly attacks the normal healthy fat cells within the subcutaneous tissue, leading to inflammation and the formation of nodules.
Diagnosis of lupus erythematosus panniculitis is often challenging but may involve a combination of clinical examination, biopsy, and laboratory tests. Treatment options for this condition typically involve the use of anti-inflammatory medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids, to reduce inflammation and relieve symptoms. In more severe cases, immunosuppressive medications or other systemic therapies may be prescribed.
While lupus erythematosus panniculitis can cause physical discomfort and cosmetic concerns, it is usually not life-threatening. However, individuals with this condition should be closely monitored by a healthcare professional, as they may have an increased risk
