How Do You Spell LEUKOCYTE ADHESION DEFICIENCY SYNDROME?

Pronunciation: [lˈuːkəsˌa͡ɪt ɐdhˈiːʒən dɪfˈɪʃənsi sˈɪndɹə͡ʊm] (IPA)

Leukocyte Adhesion Deficiency Syndrome (LADS) is a rare genetic disorder where white blood cells are unable to reach the site of an infection due to a deficiency in adhesion molecules. The spelling for "Leukocyte" is pronounced as "lu-koh-sahyt", "Adhesion" as "ad-hee-zhun" and "Deficiency" as "dih-fish-uhn-see", while "Syndrome" is pronounced as "sin-drohm". LADS patients are more prone to bacterial infections and often require lifelong treatment. Early diagnosis and appropriate management can improve their quality of life.

LEUKOCYTE ADHESION DEFICIENCY SYNDROME Meaning and Definition

  1. Leukocyte Adhesion Deficiency Syndrome (LAD syndrome) is a rare genetic disorder characterized by a deficiency in the adhesion or attachment of white blood cells, known as leukocytes, to the walls of blood vessels. This condition affects the immune system's ability to fight off infections and leads to increased susceptibility to recurrent and severe bacterial infections.

    In individuals with Leukocyte Adhesion Deficiency Syndrome, white blood cells are unable to properly adhere to the blood vessel walls and migrate to the sites of infection, impairing their ability to effectively combat bacteria. This deficiency affects various types of leukocytes, including neutrophils, monocytes, and lymphocytes, which are crucial in maintaining a healthy immune response.

    Symptoms of Leukocyte Adhesion Deficiency Syndrome usually manifest in early infancy or childhood and may include delayed separation of the umbilical cord, persistent skin and mucosal infections, poor wound healing, and gum inflammation. Affected individuals are highly prone to severe bacterial infections affecting various body systems, including the respiratory tract, skin, and gastrointestinal tract.

    Leukocyte Adhesion Deficiency Syndrome is typically caused by mutations in genes encoding proteins involved in leukocyte adhesion, such as integrins or selectins. The disorder is inherited in an autosomal recessive manner, meaning that affected individuals inherit two copies of the mutated gene, one from each parent.

    Treatment for Leukocyte Adhesion Deficiency Syndrome focuses on managing infections and preventing complications. This may involve aggressive antibiotic therapy, frequent monitoring, and administration of white blood cell transfusions to boost the immune response. In some cases, bone marrow transplantation may be considered as a potential cure.

Common Misspellings for LEUKOCYTE ADHESION DEFICIENCY SYNDROME

  • keukocyte adhesion deficiency syndrome
  • peukocyte adhesion deficiency syndrome
  • oeukocyte adhesion deficiency syndrome
  • lwukocyte adhesion deficiency syndrome
  • lsukocyte adhesion deficiency syndrome
  • ldukocyte adhesion deficiency syndrome
  • lrukocyte adhesion deficiency syndrome
  • l4ukocyte adhesion deficiency syndrome
  • l3ukocyte adhesion deficiency syndrome
  • leykocyte adhesion deficiency syndrome
  • lehkocyte adhesion deficiency syndrome
  • lejkocyte adhesion deficiency syndrome
  • leikocyte adhesion deficiency syndrome
  • le8kocyte adhesion deficiency syndrome
  • le7kocyte adhesion deficiency syndrome
  • leujocyte adhesion deficiency syndrome
  • leumocyte adhesion deficiency syndrome
  • leulocyte adhesion deficiency syndrome
  • leuoocyte adhesion deficiency syndrome
  • leuiocyte adhesion deficiency syndrome