LACTOYLGLUTATHIONE LYASE Meaning and
Definition
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Lactoylglutathione lyase, also known as glyoxalase II, is an enzyme that plays a vital role in cellular detoxification processes. It is an integral component of the glyoxalase system, which is responsible for metabolizing and detoxifying toxic metabolites such as methylglyoxal (MG).
The enzyme lactoylglutathione lyase specifically catalyzes the conversion of lactoylglutathione to d-lactate and glutathione. This reaction is essential as it prevents the accumulation of lactoylglutathione, which is formed during the detoxification process of MG.
The primary function of lactoylglutathione lyase is to catalyze the breakdown of lactoylglutathione into its constituent molecules, d-lactate, and glutathione. This reaction contributes to the regeneration of the reduced form of glutathione, an important antioxidant involved in cellular defense against oxidative stress.
Lactoylglutathione lyase is found in various tissues and organs, with particularly high concentrations observed in the liver and kidneys. Its activity is regulated by various factors, including pH and the availability of cofactors such as zinc.
Deficiency in lactoylglutathione lyase activity has been implicated in certain disease conditions, including diabetes, neurodegenerative disorders, and cancer. Conversely, increased expression of lactoylglutathione lyase has been associated with increased resistance to oxidative stress and improved cellular protection.
Overall, lactoylglutathione lyase is an essential enzyme involved in the detoxification of harmful metabolites, contributing to the overall maintenance of cellular health and protection against oxidative damage.
Common Misspellings for LACTOYLGLUTATHIONE LYASE
- kactoylglutathione lyase
- pactoylglutathione lyase
- oactoylglutathione lyase
- lzctoylglutathione lyase
- lsctoylglutathione lyase
- lwctoylglutathione lyase
- lqctoylglutathione lyase
- laxtoylglutathione lyase
- lavtoylglutathione lyase
- laftoylglutathione lyase
- ladtoylglutathione lyase
- lacroylglutathione lyase
- lacfoylglutathione lyase
- lacgoylglutathione lyase
- lacyoylglutathione lyase
- lac6oylglutathione lyase
- lac5oylglutathione lyase
- lactiylglutathione lyase
- lactkylglutathione lyase
- lactlylglutathione lyase
Etymology of LACTOYLGLUTATHIONE LYASE
The word "Lactoylglutathione Lyase" can be broken down into two parts: "lactoylglutathione" and "lyase".
1. Lactoylglutathione:
- "Lactoyl" refers to the combined form of "lactoyl", which is derived from "lactic acid".
- "Glutathione" is a compound name composed of "glutamic acid" and "cysteine".
Therefore, "lactoylglutathione" represents a compound formed from lactic acid and glutathione.
2. Lyase:
- "Lyase" is a suffix that denotes an enzyme involved in a specific reaction.
