ISLET TRANSPLANTATIONS Meaning and
Definition
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Islet transplantation is a medical procedure performed in individuals with type 1 diabetes to improve their blood sugar control. It involves the transfer of pancreatic islets, which are clusters of cells that contain insulin-producing cells called beta cells, from a donor to a recipient. These beta cells are responsible for producing the hormone insulin, which regulates blood sugar levels.
During the islet transplantation procedure, the donor islets are isolated from the pancreas of a deceased donor and purified. They are then infused into the recipient's liver through a minimally invasive procedure called percutaneous transhepatic injection. Once in the liver, the transplanted islets begin to secrete insulin, effectively replacing the function of the recipient's damaged or dysfunctional beta cells.
Islet transplantation is usually reserved for individuals with type 1 diabetes who have poor blood sugar regulation despite optimal medical management and who experience severe hypoglycemia unawareness or complications from hypoglycemia. It is not a cure for diabetes, but it can significantly improve blood sugar control, reduce the need for insulin injections, and prevent severe hypoglycemia in carefully selected patients.
The success of islet transplantation largely depends on the availability of suitable donor islets and the effectiveness of immunosuppressive medications to prevent rejection of the transplanted islets. Ongoing research is focused on optimizing the long-term outcomes and expanding the availability of islet transplantation as a treatment option for individuals with type 1 diabetes.
Common Misspellings for ISLET TRANSPLANTATIONS
- uslet transplantations
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- islrt transplantations
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Etymology of ISLET TRANSPLANTATIONS
The word "islet transplantations" is derived from several sources.
1. Islet: The term "islet" refers to a small cluster of cells. In the context of islet transplantations, it specifically refers to the Islets of Langerhans, which are tiny groups of cells found in the pancreas. These islets contain beta cells that produce and release insulin.
The word "islet" entered English in the mid-17th century from the Middle French "ilet" or "elet", meaning a small island. It was then further derived from the Latin word "insula", meaning island.
2. Transplantation: The term "transplantation" refers to the process of transferring an organ, tissue, or cells from one body to another or from one part of the body to another.
