HIV-related lymphomas refer to a group of cancerous lymphoid malignancies that occur in individuals who are infected with the human immunodeficiency virus (HIV). Lymphomas are cancers that develop in the lymphatic system, a part of the body's immune system.
HIV-related lymphomas result from the depletion of immune cells, particularly the CD4+ T cells, caused by HIV infection. This immune deficiency allows abnormal lymphocytes, which are a type of white blood cell, to proliferate and form tumors. There are two main types of HIV-related lymphoma: Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL).
Hodgkin lymphoma is characterized by the presence of Reed-Sternberg cells, which are large abnormal cells, within the affected lymph nodes. Non-Hodgkin lymphoma is a more diverse group of lymphoid malignancies and can arise from various types of lymphocytes.
HIV-related lymphomas often present with swollen lymph nodes, fever, weight loss, night sweats, fatigue, and other nonspecific symptoms. The diagnosis is typically confirmed through a lymph node biopsy, imaging tests, and blood work. Treatment options for HIV-related lymphomas typically involve a combination of chemotherapy, radiation therapy, and antiretroviral therapy (ART) to manage the HIV infection.
However, HIV-related lymphomas tend to be more aggressive and may have a poorer prognosis compared to lymphomas in individuals without HIV infection. Regular monitoring and early intervention are crucial for individuals with HIV to detect and manage lymphoma effectively.