HIV-related lymphoma is a type of cancer that affects the lymphatic system in individuals who are infected with the human immunodeficiency virus (HIV). The lymphatic system is responsible for producing and transporting white blood cells (lymphocytes) that help the body fight against infections and diseases. However, in people living with HIV, their compromised immune system due to the virus makes them more susceptible to developing lymphoma.
Lymphoma occurs when there is an abnormal growth of lymphocytes, which can form tumors in the lymph nodes, bone marrow, spleen, or other organs of the immune system. HIV-related lymphoma can be categorized into two main types: Hodgkin lymphoma and non-Hodgkin lymphoma. Hodgkin lymphoma is characterized by the presence of a specific type of cancer cell called Reed-Sternberg cells, while non-Hodgkin lymphoma encompasses a diverse group of lymphomas that do not have Reed-Sternberg cells.
HIV-related lymphoma often presents with symptoms such as swollen lymph nodes, fever, night sweats, unintended weight loss, and general fatigue. It can be challenging to diagnose as these symptoms are also commonly seen in individuals with advanced HIV infection. Treatment for HIV-related lymphoma involves a combination of chemotherapy, radiation therapy, and antiretroviral therapy (ART) to both target the cancer cells and manage the underlying HIV infection.
Due to the weakened immune system caused by HIV, the prognosis for individuals with HIV-related lymphoma is generally poorer compared to those without HIV infection. However, advances in medical treatments, including ART, have improved the management and outcomes of HIV-related lymphoma in recent years. Regular medical monitoring and early diagnosis are crucial for appropriate management and prompt initiation of therapy.