HAGEMAN TRAIT Meaning and
Definition
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The Hageman trait, also referred to as hereditary angioedema (HAE) type I, is a rare genetic disorder characterized by a deficiency or malfunctioning of the C1 inhibitor protein. This autosomal dominant disease affects the immune system and results in recurrent episodes of non-pitting edema or swelling in various body parts.
Individuals with the Hageman trait typically experience recurrent attacks of angioedema, causing swelling in the face, extremities, gastrointestinal tract, and airways. These episodes can last up to several days and are often unpredictable in their frequency and severity. The triggers for the attacks may include emotional stress, injury, hormonal changes, or certain medications.
The deficiency or malfunctioning of the C1 inhibitor protein leads to an uncontrolled activation of the complement and kinin pathways, resulting in increased levels of bradykinin, a potent vasodilator, and mediator of swelling. The Hageman trait is often diagnosed through genetic testing, complement studies, and clinical evaluation of symptoms.
Treatment for HAE typically involves managing and preventing attacks through the use of prophylactic medications that enhance C1 inhibitor levels or block bradykinin receptors. Acute attacks can be treated with medications that reduce swelling and inhibit bradykinin activity. Other measures, such as stress reduction, avoidance of triggers, and prompt medical intervention during attacks, may also be recommended to effectively manage the Hageman trait.
Overall, the Hageman trait is a rare hereditary disorder characterized by recurrent episodes of angioedema caused by a deficiency or malfunctioning of the C1 inhibitor protein, disrupting the regulation of the complement and kinin pathways.
Common Misspellings for HAGEMAN TRAIT
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Etymology of HAGEMAN TRAIT
The term "Hageman trait" refers to an observation made by Dr. John H. J. Hageman in 1937. The word "Hageman" in this context is derived from Dr. Hageman's last name, as he was the first person to identify and describe this trait. Therefore, the etymology of the word "Hageman trait" can be traced back to Dr. Hageman himself.
