GLYCOPROTEIN IB Meaning and
Definition
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Glycoprotein Ib (GpIb) is a transmembrane glycoprotein that serves as a receptor for von Willebrand factor (vWF) on the platelet surface. It is a complex protein composed of different subunits, including GpIbα, GpIbβ, and GpIX. GpIbα is the main subunit that binds to vWF, while GpIbβ and GpIX stabilize and support its function.
GpIb is primarily found on platelets, specialized blood cells that play a crucial role in hemostasis, the process of stopping bleeding. This glycoprotein is responsible for platelet adhesion to damaged blood vessel walls and the formation of platelet clumps, or aggregates, at the site of injury.
The binding of vWF to GpIb triggers a series of intracellular signaling events that contribute to platelet activation, aggregation, and the formation of a blood clot. Additionally, GpIb helps mediate platelet rolling along the blood vessel walls, allowing the platelets to efficiently survey the vasculature for areas of injury and inflammation.
Mutations or abnormalities in the GpIb complex can lead to bleeding disorders, such as Bernard-Soulier syndrome, where platelets are dysfunctional or have a reduced number of GpIb receptors. Conversely, certain bacterial and viral pathogens can exploit GpIb to attach to platelets, promoting infection and pathogenesis.
Overall, GpIb is a critical glycoprotein involved in platelet function, hemostasis, and thrombosis, making it an important target for therapeutic interventions and research in the field of cardiovascular health.
Common Misspellings for GLYCOPROTEIN IB
Etymology of GLYCOPROTEIN IB
The etymology of the word "Glycoprotein Ib" can be broken down as follows:
1. Glyco-: The prefix "glyco-" comes from the Greek word "glukus", meaning sweet or sugar. It is commonly used in scientific terminology to refer to carbohydrates or sugars.
2. Protein: The term "protein" originates from the Greek word "proteios", which means "primary" or "of prime importance". Proteins are large biomolecules consisting of amino acids, and they play essential roles in various biological processes.
3. Ib: The suffix "Ib" in "Glycoprotein Ib" is a specific designation. In many cases, protein nomenclature assigns letters or numbers to refer to specific isoforms or variants within a larger protein family.
Similar spelling words for GLYCOPROTEIN IB
- glycoprotein ia/iia,
- glycoprotein iib/iiia,
- glycoprotein ib/ix/v,
- Glycoprotein p,
- Membrane Glycoprotein,
- Glycoprotein gp68,
- Mo1 Glycoprotein,
- Mo Glycoprotein,
- P Glycoprotein,
- p150,95 Glycoprotein,
- Glycoprotein 330,
- Glycoprotein gp,
- Glycoprotein Sialyltransferase,
- Opsonic Glycoprotein,
- HANA Glycoprotein,
- SPARC Glycoprotein,
- glycoprotein vi,
- glycoprotein hormone,
- Glycoprotein Sialyltransferases,
- amyloidogenic glycoprotein,
- Surface Glycoprotein,
- Glycoprotein, p150,95,
- P0 Glycoprotein.
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