GAMMA AMINOBUTYRIC ACID MODULATORS Meaning and
Definition
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Gamma aminobutyric acid (GABA) modulators are a class of pharmaceutical drugs or compounds that exert their effects on the central nervous system by modulating the function of the GABA neurotransmitter system. GABA is an inhibitory neurotransmitter that plays a crucial role in regulating brain activity and maintaining proper neurotransmission balance. GABA modulators can act by either enhancing or inhibiting the activity of GABA receptors, thereby affecting the overall excitability and inhibitory signaling in the brain.
GABA modulators that enhance GABAergic activity are classified as GABA agonists or positive allosteric modulators. These compounds increase the activity of GABA receptors by binding to specific receptor sites and potentiating the effects of GABA. By doing so, they promote inhibitory neurotransmission, leading to sedative, anxiolytic, anticonvulsant, and muscle relaxant effects. Examples of GABA agonists include benzodiazepines, barbiturates, and certain antiepileptic drugs.
On the other hand, GABA modulators that inhibit GABAergic activity are called GABA antagonists or negative allosteric modulators. These substances block or reduce the activity of GABA receptors, resulting in decreased inhibition and increased excitability of nerve cells. Drugs that act as GABA antagonists are primarily used as convulsants in medical contexts.
Overall, gamma aminobutyric acid (GABA) modulators are a diverse group of compounds that target the GABA neurotransmitter system to influence brain activity. Their usage can vary depending on the need to enhance inhibitory neurotransmission or induce excitatory effects, with potential applications in treating conditions such as anxiety disorders, epilepsy, insomnia, and muscle spasticity.
Common Misspellings for GAMMA AMINOBUTYRIC ACID MODULATORS
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