GAMMA AMINOBUTYRIC ACID AGENTS Meaning and
Definition
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Gamma-aminobutyric acid (GABA) agents refer to a class of drugs or substances that affect the functions of gamma-aminobutyric acid in the central nervous system (CNS). GABA is the primary inhibitory neurotransmitter in the brain, responsible for reducing neuronal excitability. GABA agents modulate the activity of GABA receptors, influencing the conductance of chloride ions and hyperpolarizing the neuronal membrane, which ultimately leads to a decrease in neuronal firing and a calming effect on the CNS.
These agents can be broadly categorized into two groups: GABA agonists and GABA modulators. GABA agonists directly bind to GABA receptors, stimulating them to enhance the inhibitory effect of GABA. Examples include benzodiazepines, barbiturates, and alcohol. On the other hand, GABA modulators do not bind directly to GABA receptors but instead affect GABA neurotransmission indirectly. They include drugs such as anticonvulsants, anxiolytics, and sedatives, which work by influencing GABA receptor activity through various mechanisms, such as increasing GABA synthesis, inhibiting GABA degradation, or facilitating GABA release.
Gamma-aminobutyric acid agents are commonly used in the treatment of various medical conditions, including anxiety disorders, epilepsy, insomnia, muscle spasms, and mood disorders. However, due to their potential for sedation and other side effects, GABA agents should be used cautiously and under medical supervision.
Common Misspellings for GAMMA AMINOBUTYRIC ACID AGENTS
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