How Do You Spell FUMARASE?

Pronunciation: [fjˈuːmɐɹˌe͡ɪz] (IPA)

Fumarase is a word commonly used in the field of biochemistry, referring to an enzyme involved in the Krebs cycle. The word is spelled as fu·ma·rase (fyo͞o′mə-rās′) in IPA phonetic transcription. The first syllable is pronounced with a 'fy' sound, representing the 'f' and 'y' sounds together. The second syllable is pronounced with a short 'u' and 'm' sound, followed by a long 'a' and a short 'r' sound. The last syllable is pronounced with a long 'a' sound and a 'z' sound, represented by 's' in the spelling.

FUMARASE Meaning and Definition

1. Fumarase is an enzyme that plays a crucial role in the cellular energy production process called the citric acid cycle, also known as the Krebs cycle. It is classified as a lyase enzyme, specifically catalyzing the reversible hydration/dehydration of fumarate to malate.

   In more technical terms, fumarase facilitates the interconversion of fumarate, a four-carbon compound, and L-malate, a four-carbon dicarboxylic acid. This enzymatic reaction occurs with the addition or removal of a water molecule. The enzyme acts as a catalyst, speeding up the conversion without itself being consumed in the process.

   Fumarase is essential for the efficient functioning of the citric acid cycle, as it contributes to the generation of adenosine triphosphate (ATP), the cell's primary energy source. This enzyme ensures the flow of substrates and intermediates within the cycle and aids in maintaining the cycle's equilibrium.

   Notably, fumarase deficiency in humans is an inherited metabolic disorder that can lead to severe health complications. Fumarase deficiencies are linked to an array of symptoms, including neurological abnormalities, developmental delays, muscle weakness, and impaired growth. Such deficiencies can be caused by mutations in the fumarase gene, leading to reduced or impaired enzymatic activity.

   Overall, fumarase is a highly important enzyme involved in energy production and overall cellular metabolism. Its activity and proper functioning are integral to various biological processes and the overall maintenance of cellular homeostasis.

Common Misspellings for FUMARASE

• fumarus
• dumarase
• cumarase
• vumarase
• gumarase
• tumarase
• rumarase
• fymarase
• fhmarase
• fjmarase
• fimarase
• f8marase
• f7marase
• funarase
• fukarase
• fujarase
• fumzrase
• fumsrase
• fumwrase
• fumqrase

Etymology of FUMARASE

The word "fumarase" is derived from "fumaric acid" and the suffix "-ase".

"Fumaric acid" comes from the Latin word "fumus", which means "smoke", as fumaric acid was initially discovered in the smoke of burning pine trees. The acid was named for its presence in fumitory, a plant with medicinal properties.

The suffix "-ase" is a common suffix used in biochemistry to indicate an enzyme. So, "fumarase" refers to the enzyme that catalyzes the reaction involving fumaric acid.