Pronunciation: [fˈɒɹən bˈɒdi ɹɪˈakʃən] (IPA) 
Correct spelling for the English word "Foreign Body Reaction" is [fˈɒɹən bˈɒdi ɹɪˈakʃən], [fˈɒɹən bˈɒdi ɹɪˈakʃən], [f_ˈɒ_ɹ_ə_n b_ˈɒ_d_i ɹ_ɪ__ˈa_k_ʃ_ə_n] (IPA phonetic alphabet).
Foreign body reaction is a physiological response of the immune system triggered by the introduction of a foreign substance into the body. It is a protective mechanism aimed at isolating and eliminating the foreign material in order to maintain tissue integrity and preserve the body's overall health.
When a foreign body, such as an implant, a medical device, or even simple particles like dust or splinters, enters and remains within the body, the immune system recognizes it as non-self and activates an immune response. This reaction typically involves inflammation characterized by redness, swelling, pain, and warmth around the site of the foreign material.
The immune system attempts to encapsulate the foreign body by coating it with fibrous tissue to prevent its dissemination and minimize its potential harm. This protective mechanism is mediated by various immune cells and molecules such as macrophages, neutrophils, and cytokines.
While the foreign body reaction is an important defense mechanism, it can also lead to complications. In some cases, the body's response may be excessive, resulting in chronic inflammation and tissue damage. This can lead to implant failure or rejection in the case of medical devices or grafts.
Foreign body reactions can vary in severity depending on the nature of the foreign material, its size, and its location within the body. Understanding and managing foreign body reactions is crucial for healthcare professionals to optimize patient outcomes and minimize associated complications.
