CANCER STEM CELLS Meaning and
Definition
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Cancer stem cells refer to a small subpopulation of cells within a tumor that possess the ability to self-renew and differentiate into various cell types that constitute the tumor mass. These stem cells are considered the driving force behind tumor development, progression, and metastasis.
Unlike normal stem cells, cancer stem cells exhibit uncontrolled growth, evade normal regulatory mechanisms, and have the capability to resist conventional cancer treatments such as chemotherapy and radiation therapy. They are believed to be responsible for tumor recurrence and resistance to therapy. Cancer stem cells possess distinct molecular and biochemical characteristics that differentiate them from other tumor cells, including enhanced DNA repair mechanisms, increased drug efflux pumps, and activation of signaling pathways associated with cell survival and tumor growth.
The identification and understanding of cancer stem cells have significant implications for cancer research and treatment, as targeting these cells could potentially lead to more effective therapies and better patient outcomes. Scientists are continuously studying the properties and behavior of cancer stem cells to devise novel strategies for targeted therapies and personalized medicine approaches. Developing therapies specifically to target cancer stem cells may prevent disease recurrence and improve patient survival rates.
